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Does the introduction explain the objective of the research presented in the preprint?

Yes

The introduction clearly explains the objective of the study by presenting information on how antibody titers can be cross-reactive that are both neutralizing and increase the risk of infection. This is further built upon in how the paper describes the implication of previous DENV or ZIKV infections and the increased risk they pose.

Are the methods well-suited for this research?

Somewhat appropriate

The methods and materials that were described were thorough and properly executed and produced a solid foundation on which one would be able to generate meaningful discourse. The methods could be further enhanced if the study design had accounted for potential confounding variables that may have been prevalent during the time of the study that was being observed.

Are the conclusions supported by the data?

Highly supported

Are the data presentations, including visualizations, well-suited to represent the data?

Somewhat appropriate and clear

How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research?

Somewhat clearly

Is the preprint likely to advance academic knowledge?

Somewhat likely

Would it benefit from language editing?

No

Would you recommend this preprint to others?

Yes, it’s of high quality

Is it ready for attention from an editor, publisher or broader audience?

Yes, after minor changes

Competing interests

The author declares that they have no competing interests.