Structured PREreview of Asymmetric tethering by exocystin vitrorequires a Rab GTPase, a v-SNARE and a Sac1-sensitive phosphoinositide lipid

by Rinalda Proko

Does the introduction explain the objective of the research presented in the preprint?: Yes
Are the methods well-suited for this research?: Highly appropriate
Are the conclusions supported by the data?: Somewhat supported; It is generalized that the tethering reaction to the plasma membrane need both Rabs and R-SNAREs, while it was study only on representative per each of them such as Sec4 and Sso1.
Are the data presentations, including visualizations, well-suited to represent the data?: Somewhat appropriate and clear; The images from the microscopy need to have higher quality and scale bars. Figure legends are lacking the number of samples analyzed.
How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research?: Neither clearly nor unclearly; They need to discuss more the results based on similar findings in other model organisms.
Is the preprint likely to advance academic knowledge?: Moderately likely
Would it benefit from language editing?: Yes; It might need more logical flow and development of the paragraph as sometimes the sentences are short.
Would you recommend this preprint to others?: Yes, but it needs to be improved
Is it ready for attention from an editor, publisher or broader audience?: Yes, after minor changes; It might need work regarding the discussion of the results.

Competing interests