PREreviews de “Endoscopic One-Nostril Trans-Septal Trans-Sphenoidal Approach for Pitutary Tumors: Back to the Past—A Multi-Center Preliminary Experience and Literature Review”

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Endoscopic One-Nostril Trans-Septal Trans-Sphenoidal Approach for Pitutary Tumors: Back to the Past—A Multi-Center Preliminary Experience and Literature Review

por Denis Aiudi, Alessio Iacoangeli, Andrea Mattioli, Simone Russo, Massimo Balbi, Stefano Vecchioni, Michele Luzi, Roberto Trignani, Alberto Califano, Ruggero Antonini, Mario Chiapponi, Fabio Greco, Fabrizio Salvinelli, Kenan Arnautovic, Maurizio Iacoangeli y Maurizio Gladi

Publicado: 9 de diciembre de 2025
Servidor: Preprints.org
DOI: 10.20944/preprints202512.0583.v1

Resumen

This study presents the Endoscopic One Nostril Transseptal Transsphenoidal Approach (EONOTTA) as a minimally invasive surgical technique for se-lected cases of pituitary macroadenomas. Derived from the classic endoscopic endonasal approach, EONOTTA allows excellent exposure of the sellar re-gion while preserving nasal mucosa and olfactory function. The technique offers comparable disease control to standard endoscopic endonasal ap-proaches, with reduced sinonasal morbidity and postoperative discomfort. Despite limitations such as retrospective design and small sample size, findings support EONOTTA as a safe, efficient alternative for non-extended pituitary tumors requiring limited surgical exposure.

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PREreviews de Endoscopic One-Nostril Trans-Septal Trans-Sphenoidal Approach for Pitutary Tumors: Back to the Past—A Multi-Center Preliminary Experience and Literature Review

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