Artificial Intelligence (AI) has achieved remarkable successes, but it continues to face critical challenges—including inefficiency, limited interpretability, lack of robustness, alignment issues, and high energy consumption. Quantum computing offers a promising path to fundamentally accelerate and enhance AI by leveraging quantum parallelism and entanglement. This paper proposes QHM—Quantum Hybrid Multimodal, a unified framework that integrates superconducting and topological quantum computing into multimodal AI architectures. We establish a theoretical foundation for embedding quantum subroutines—such as a Quantum Self-Attention Neural Network (QSANN) and Quantum Enhanced Quantum Approximate Optimization Algorithm (QAOA)- QQAOA—within classical deep learning models. We survey key quantum algorithms, including Grover’s search, the HHL algorithm for solving linear systems, QAOA, and variational quantum circuits, evaluating their computational complexity and suitability for AI workloads. We also analyze cutting-edge quantum hardware platforms: superconducting qubit systems like Google’s 105-qubit Willow, IBM’s 1,121-qubit Condor, Amazon’s bosonic Ocelot, and Microsoft’s topological Majorana-1, discussing their potential for accelerating AI. The paper explores how quantum resources can enhance large language models, Transformers, mixture-of-experts architectures, and cross-modal learning via quantum-accelerated similarity search, attention mechanisms, and optimization techniques. We also examine practical engineering challenges, including cryogenic cooling, control electronics, qubit noise, quantum error correction, and data encoding overhead, offering a cost-benefit analysis. An implementation roadmap is outlined, progressing from classical simulations to hybrid quantum-classical prototypes, and ultimately to fully integrated systems. We propose benchmarking strategies to evaluate quantum-AI performance relative to classical baselines. Compared to conventional approaches, the QHM hybrid framework promises improved computational scaling and novel capabilities—such as faster search and more efficient training—while acknowledging current limitations in noise and infrastructure. We conclude by outlining future directions for developing quantum-enhanced AI systems that are more efficient, interpretable, and aligned with human values, and we discuss broader implications for AI safety and sustainability.