MacDonald, Balaji, and Chesler investigated molecular mechanisms of pain using mouse genetics, behavior, and cell-based assays. The authors examined a fundamental question in the field: what signaling molecules are necessary for peripheral afferents to transform noxious sensory inputs into pain…
Proper relay of pain sensation to the brain is critical for health and survival, yet how this is achieved at the molecular levels remains less understood. In this study, McDonald et al. sought to resolve the contributions of glutamate and neuropeptides in transmitting pain signals in mice, which…
Proper relay of pain sensation to the brain is critical for health and survival, yet how this is achieved at the molecular levels remains less understood. In this study, McDonald et al. sought to resolve the contributions of glutamate and neuropeptides in transmitting pain signals in mice, which…