PREreviews of “Immunosuppression Drugs Exhibit Differential Effects on Endothelial Cell Function”

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Immunosuppression Drugs Exhibit Differential Effects on Endothelial Cell Function

by Aly Elezaby, Ryan Dexheimer, David Wu, Sze Yu Chan, Ian Y. Chen, Nazish Sayed, and Karim Sallam

Posted: November 3, 2024
Server: bioRxiv
DOI: 10.1101/2024.10.31.620858

Abstract

Immunosuppressive medications are widely used to treat patients with neoplasms, autoimmune conditions, and solid organ transplants. Prior studies indicate that immunosuppression drugs can cause adverse vascular remodeling. Given the systemic effects of the drugs, elucidating cell-type specific drug-effects has been challenging. We utilized induced pluripotent stem-cell derived endothelial cells to investigate the role of widely used immunosuppression drugs on endothelial function. We found that among immunosuppression agents, sirolimus reduced basic endothelial cell functions including cell migration, proliferation, acetylated LDL uptake, and angiogenesis properties; while tacrolimus only reduced nitric oxide release. This model allows for investigation of differential effect of immunosuppression drugs on endothelial function that can elucidate mechanisms contributing to adverse vascular profiles observed clinically.

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PREreview by Arpita Ghosh et al.

Authored by Arpita Ghosh, Arpita Ghosh, Chen Yang, and 7 other authors
Brief summary of the study :
- The study investigates the differential effects of immunosuppressive drugs, sirolimus and tacrolimus, on endothelial cell function using iPSC-derived endothelial cells. The findings are significant as they provide mechanistic insights into vascular remodeling in…
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PREreviews of Immunosuppression Drugs Exhibit Differential Effects on Endothelial Cell Function

1 PREreview