Write a PREreview

Analysis of iPLA2-VIA Gene Expression in The CNS of Larvae and AdultDrosophila MelanogasterFlies

by Gabriel Moura

Posted: July 19, 2024
Server: bioRxiv
DOI: 10.1101/2024.07.17.603941

This study aimed to investigate the expression levels of the iPLA2-VIA gene (FlyBase: FBgn0035800) in the nervous tissue ofDrosophila melanogaster(FlyBase: FBsp00000008) larvae and adults. The gene was identified using the FlyBase database and the HGNC database. The results of our experiments indicated that the expression levels of the gene were consistent between the larval and adult stages, with higher expression of Larvae than of Adult. We also found that the gene was expressed in the CNS, digestive system, fat body, salivary glands, ovaries, and accessory glands. Furthermore, PLA2G6 (Gene ID: 8398) knockout resulted in lethality, fertility problems, tissue formation defects, and neurological abnormalities, highlighting its essential biological roles in neural health and disease. Our findings could inform future studies focused on the gene’s involvement in neural development and its potential as a therapeutic target for neurodegenerative diseases.

You can write a PREreview of Analysis of iPLA2-VIA Gene Expression in The CNS of Larvae and AdultDrosophila MelanogasterFlies. A PREreview is a review of a preprint and can vary from a few sentences to a lengthy report, similar to a journal-organized peer-review report.

Before you start

We will ask you to log in with your ORCID iD. If you don’t have an iD, you can create one.