PREreviews of Senolytics enhance longevity inCaenorhabditis elegansby altering betaine metabolism

2 PREreviews

1. PREreview by Youchen Guan of the HHMI Transparent and Accountable Peer Review Training Pilot

   Authored by Youchen Guan of the HHMI Transparent and Accountable Peer Review Training Pilot

   In this manuscript, Lan et al. investigate metabolomic changes associated with the aging process and explore the impact of senolytic drugs on Caenorhabditis elegans longevity. The authors highlight betaine as a key metabolite regulated by anti-aging drugs including minocycline, metformin, and…

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2. PREreview by Lang Ding of the HHMI Transparent and Accountable Peer Review Training Pilot

   Authored by Lang Ding of the HHMI Transparent and Accountable Peer Review Training Pilot

   This manuscript investigates key metabolites in regulating aging and longevity. The authors found that the concentration of betaine in the serum of elderly humans and aged worms is lower than in their younger counterparts, as determined by NMR metabolomics. They also have examined several…

   Read the PREreview by Lang Ding of the HHMI Transparent and Accountable Peer Review Training Pilot