PREreviews of “Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection”

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Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection

by Alexander Lercher, Jin-Gyu Cheong, Chenyang Jiang, Hans-Heinrich Hoffmann, Alison W. Ashbrook, Yue S. Yin, Corrine Quirk, Emma J. DeGrace, Luis Chiriboga, Brad R. Rosenberg, Steven Z. Josefowicz, and Charles M. Rice

Posted: November 27, 2023
Server: bioRxiv
DOI: 10.1101/2023.11.24.568354

Abstract

Pathogen encounter results in long-lasting epigenetic imprinting that shapes diseases caused by heterologous pathogens. The breadth of this innate immune memory is of particular interest in the context of respiratory pathogens with increased pandemic potential and wide-ranging impact on global health. Here, we investigated epigenetic imprinting across cell lineages in a disease relevant murine model of SARS-CoV-2 recovery. Past SARS-CoV-2 infection resulted in increased chromatin accessibility of type I interferon (IFN-I) related transcription factors in airway-resident macrophages. Mechanistically, establishment of this innate immune memory required viral pattern recognition and canonical IFN-I signaling and augmented secondary antiviral responses. Past SARS-CoV-2 infection ameliorated disease caused by the heterologous respiratory pathogen influenza A virus. Insights into innate immune memory and how it affects subsequent infections with heterologous pathogens to influence disease pathology could facilitate the development of broadly effective therapeutic strategies.

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PREreview by Hickory Chameleon

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PREreviews of Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection

1 PREreview