Write a PREreview

Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses

by Susanna E. Barouch, Taras M. Chicz, Ross Blanc, Domenic R. Barbati, Lily J. Parker, Xin Tong, and Ryan P. McNamara

Posted: September 12, 2023
Server: bioRxiv
DOI: 10.1101/2023.09.12.557347

The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, the immunogenicity of concurrent versus separate administration of these vaccines remains unclear. Here, we analyzed antibody responses in healthcare workers who received the bivalent COVID-19 booster and the influenza vaccine on the same day or different days. IgG1 responses to SARS-CoV-2 Spike were higher at peak immunogenicity and 6 months following concurrent administration compared with separate administration of the COVID-19 and influenza vaccines. These data suggest that concurrent administration of these vaccines may yield higher and more durable SARS-CoV-2 antibody responses.

You can write a PREreview of Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses. A PREreview is a review of a preprint and can vary from a few sentences to a lengthy report, similar to a journal-organized peer-review report.

Before you start

We will ask you to log in with your ORCID iD. If you don’t have an iD, you can create one.