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Autophagy is a self-eating intracellular degradation process in eukaryotic cell. Muti-pathways have been found can regulate autophagy activity through different mechanisms. In this study, we found that a nuclear abundant RNA binding protein, hnRNP R is involved in autophagy process by binding with ATG3, p62, Lamp1, LC3 and ATG9. On the other hand, hnRNP R also can regulate autophagy, we found depletion hnRNP R can activate the autophagy flux and activity. Furthermore, we also checked that autophagy has not connection with stress granules. This finding highlights some novel and nuclear located RNA binding proteins play important role in the regulation of autophagy activity.