PREreviews of “Increase in SARS-CoV-2 RBD-specific IgA and IgG Antibodies in Human Milk from Lactating Women Following the COVID-19 Booster Vaccination” | PREreview

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Increase in SARS-CoV-2 RBD-specific IgA and IgG Antibodies in Human Milk from Lactating Women Following the COVID-19 Booster Vaccination

by Andrea M. Henle

Posted: February 24, 2022
Server: medRxiv
DOI: 10.1101/2022.02.23.22271414

Abstract

The CDC recommended a booster dose of the Pfizer-BioNTech Comirnaty (BNT162b2) COVID-19 mRNA vaccine in September 2021 for high-risk individuals. Pregnant and high-risk lactating women were encouraged to receive the booster to obtain potential prolonged protection for themselves and their infants. This study investigated the ability of the booster vaccine to increase IgA and IgG antibodies specific to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein in human milk compared to levels pre-booster. We found a significant increase in both anti-RBD-specific IgA and IgG antibodies in human milk 1-2 weeks after the Pfizer-BioNTech booster and at the study endpoint (60 days post-booster). These results suggest the booster vaccination enhances SARS-CoV-2 specific immunity in human breast milk, which may be protective for infants.

Key Points

Abs to SARS-COV-2 RBD are detected in blood ≥60 days post-Pfizer-BioNTech booster.
Human milk Abs to SARS-COV-2 RBD are higher ≥60 days post-booster vs pre-booster.

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1 Rapid PREreview

by Rebeccah Lijek

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Aggregated Rapid PREreviews
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Are the results likely to lead to future research?	100%	0%	0%	0%
Is sufficient detail provided to allow reproduction of the study?	100%	0%	0%	0%
Are the methods and statistics appropriate for the analysis?	100%	0%	0%	0%
Are the principal conclusions supported by the data and analysis?	0%	100%	0%	0%
Does the manuscript discuss limitations?	100%	0%	0%	0%
Have the authors adequately discussed ethical concerns?	0%	0%	100%	0%
Does the manuscript include new data?	100%	0%	0%	0%
Are the data used in the manuscript available?	0%	0%	100%	0%
Is the code used in the manuscript available?	0%	0%	100%	0%
Would you recommend this manuscript to others?	100%	0%	0%	0%
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1 PREreview

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PREreview by Rebeccah Lijek

Authored by Rebeccah Lijek

Review of: Henle, A. 2022. “Increase in SARS-CoV-2 RBD-specific IgA and IgG Antibodies in Human Milk from Lactating Women Following the COVID-19 Booster Vaccination.” medRxiv. DOI: https://doi.org/10.1101/2022.02.23.22271414
This review was written collaboratively by undergraduates at Mount Holyoke…

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