PREreviews of “Assessment of Agaricus bisporus Mushroom as Protective Agent Against Ultraviolet Exposure” | PREreview

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Assessment of Agaricus bisporus Mushroom as Protective Agent Against Ultraviolet Exposure

by Chae Yeon Hwang, Yuniwaty Halim, Marcelia Sugata, Dela Rosa, Sherlyn Putri Wijaya, and Eden Steven

Posted: October 24, 2021
Server: bioRxiv
DOI: 10.1101/2021.10.21.465111

Abstract

Mushrooms are versatile materials with applications including but not limited to food, cosmetics, and pharmaceutical industries. In this work, the potential of the common button mushroom, Agaricus bisporus, as a protective agent against ultraviolet exposure was assessed. The assessment was done by investigating the radical scavenging activity, sun protecting capability, and tyrosinase inhibiting properties of Agaricus bisporus ethanolic extract. The extraction was carried out using absolute ethanol as its solvent at low to room temperatures. The bioactive components of the ethanolic extract were analysed for its phenolic and flavonoid contents quantitatively, while other phytochemical agents were analysed qualitatively. The Agaricus bisporus ethanolic extract was found exhibit varying degree of activity in all of the assessment. We found low radical scavenging ability with %RSA IC50 of ∼5456 μg/mL, low to moderate sun protecting factor of ∼5.355 at 5000 ppm concentration, and high tyrosinase inhibition property with IC50 of ∼2 μg/mL. The high tyrosinase inhibition property was found to correlate with relatively high total phenolic content of ∼1143 mg GAE/100g for Agaricus bisporus and the presence of terpenoid in the ethanolic extract.

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9 Rapid PREreviews

by Saeed Shafiei Sabet, Jessica Polka, Iratxe Puebla, Isha Soni, Daniela Saderi, Antony Gruness, Hotpink Crow, Nikhil Bhandarkar, and Sonisilpa Mohapatra

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Aggregated Rapid PREreviews
Question	Yes	Unsure	N/A	No
Are the findings novel?	100%	0%	0%	0%
Are the results likely to lead to future research?	89%	0%	0%	11%
Is sufficient detail provided to allow reproduction of the study?	11%	44%	0%	44%
Are the methods and statistics appropriate for the analysis?	22%	33%	0%	44%
Are the principal conclusions supported by the data and analysis?	44%	11%	0%	44%
Does the manuscript discuss limitations?	56%	11%	0%	33%
Have the authors adequately discussed ethical concerns?	0%	11%	78%	11%
Does the manuscript include new data?	100%	0%	0%	0%
Are the data used in the manuscript available?	0%	78%	0%	22%
Is the code used in the manuscript available?	0%	11%	67%	22%
Would you recommend this manuscript to others?	78%	0%	0%	22%
Do you recommend this manuscript for peer review?	100%	0%	0%	0%

1 PREreview

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PREreview by Daniela Saderi et al.

Authored by Daniela Saderi, Sonisilpa Mohapatra, Nikhil Bhandarkar, Antony Gruness, Isha Soni, Iratxe Puebla, and Jessica Polka

This PREreview is the result of a virtual, live-streamed preprint journal club organized and hosted by PREreview and ASAPbio Preprint Reviewer Recruitment Network.
In their preprint, YC Hwang et al. characterize some of the biophysical and biochemical properties of extracts from the mushroom Agaric…

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