We’ve recently replaced Rapid PREreviews with <a href="https://content.prereview.org/introducing-structured-prereviews-on-prereview-org/" >Structured PREreviews</a >.
You can <a href="/preprints/doi-10.1101-2021.09.10.459791/write-a-prereview">write a Structured PREreview</a> now.
We’ll be updating older Rapid PREreviews like these soon.
| Question | Yes | Unsure | N/A | No |
|---|---|---|---|---|
| Are the findings novel? | 100% | 0% | 0% | 0% |
| Are the results likely to lead to future research? | 100% | 0% | 0% | 0% |
| Is sufficient detail provided to allow reproduction of the study? | 100% | 0% | 0% | 0% |
| Are the methods and statistics appropriate for the analysis? | 100% | 0% | 0% | 0% |
| Are the principal conclusions supported by the data and analysis? | 100% | 0% | 0% | 0% |
| Does the manuscript discuss limitations? | 0% | 0% | 0% | 100% |
| Have the authors adequately discussed ethical concerns? | 0% | 0% | 100% | 0% |
| Does the manuscript include new data? | 100% | 0% | 0% | 0% |
| Are the data used in the manuscript available? | 0% | 100% | 0% | 0% |
| Is the code used in the manuscript available? | 0% | 0% | 100% | 0% |
| Would you recommend this manuscript to others? | 100% | 0% | 0% | 0% |
| Do you recommend this manuscript for peer review? | 100% | 0% | 0% | 0% |
In this article, the authors convincingly demonstrate that the ubiquitin E3 ligase HOIL-1 can ubiquitylate in vitro oligosaccharides, only the second example ever reported of a non-proteinaceous ubiquitylation substrate. They also observe that mice harbouring a catalytic dead version of HOIL-1…