We’ve recently replaced Rapid PREreviews with Structured PREreviews.
You can write a Structured PREreview now.
We’ll be updating older Rapid PREreviews like these soon.
| Question | Yes | Unsure | N/A | No |
|---|---|---|---|---|
| Are the findings novel? | 100% | 0% | 0% | 0% |
| Are the results likely to lead to future research? | 100% | 0% | 0% | 0% |
| Is sufficient detail provided to allow reproduction of the study? | 100% | 0% | 0% | 0% |
| Are the methods and statistics appropriate for the analysis? | 100% | 0% | 0% | 0% |
| Are the principal conclusions supported by the data and analysis? | 100% | 0% | 0% | 0% |
| Does the manuscript discuss limitations? | 50% | 50% | 0% | 0% |
| Have the authors adequately discussed ethical concerns? | 0% | 0% | 100% | 0% |
| Does the manuscript include new data? | 100% | 0% | 0% | 0% |
| Are the data used in the manuscript available? | 0% | 100% | 0% | 0% |
| Is the code used in the manuscript available? | 0% | 0% | 100% | 0% |
| Would you recommend this manuscript to others? | 100% | 0% | 0% | 0% |
| Do you recommend this manuscript for peer review? | 100% | 0% | 0% | 0% |
Summary of the work:
Authors found a novel role of LAMP1 in Drosophila which is not essential for autophagy or viability but rather required in lipid metabolism compared to its vertebrate homologs where its known to show autophagy defects and embryonic lethality. They found homozygous Lamp1 mutants…
LAMP proteins localize at the lysosomal membrane, controlling autophagy-related processes but also lipid transport and metabolism. While it is well-demonstrated the existence of a link between LAMP misfunction and human diseases, the mechanisms underlying LAMP functions are still poorly…