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Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women

by Mai He, Priya Skaria, Kasey Kreutz, Ling Chen, Ian Hagemann, Ebony B. Carter, Indira U. Mysorekar, D Michael Nelson, John Pfeifer, and Louis P. Dehner

Posted: August 12, 2020
Server: medRxiv
DOI: 10.1101/2020.08.11.20173005

Background

This study aims to investigate whether maternal SARS-CoV-2 status affect placental pathology.

Methods

A retrospective case-control study was conducted by reviewing charts and slides of placentas between April 1 to July 24, 2020. Clinical history of “COVID-19” were searched in Pathology Database (CoPath). Controls were matched with SARS-CoV-2-negative women with singleton deliveries in the 3^rd-trimester. Individual and group, pathological features were extracted from placental pathology reports.

Results

Twenty-one 3^rd-trimester, placentas from SARS-CoV-2-positive women were identified and compared to 20 placentas from SARS-CoV-2-negative women. There were no significant differences in individual or group gross or microscopic pathological features between the groups. Within the SARS-CoV-2+ group, there are no differences between symptomatic and asymptomatic women.

Conclusion

Placentas from SARS-CoV-2-positive women do not demonstrate a specific pathological pattern. Pregnancy complicated with COVID-19 during the 3^rd trimester does not have a demonstrable effect on placental structure and pathology.

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