Proteostasis and Cancer Team INSERM U1242

The Proteostasis and Cancer team is aiming at characterizing how protein homeostasis (a.k.a. proteostasis) control might play a role in cancer development. In particular, the team focuses principally (but not exclusively) on the signalling pathways sustaining proteostasis in the Endoplasmic Reticulum (ER), the clinical relevance of such mechanisms, and the potential of their therapeutic targeting in solid tumours (mainly brain and breast cancers).

This club will provide pre-reviews of preprints as part of our team’s journal clubs. We thereby aim to provide constructive criticism to the authors while training the students and postdoctoral researchers in our team to review articles.

Club leads

Elodie Lafont

PREreviews

1. Elodie Lafont, Eric Chevet, and Ketsia Bakambamba reviewed Identification of Glucosidase II that regulates STIM1 activation dynamics

   • Immunology
   • Sensory Systems
   • Microbiology

   Review published

   July 27, 2024

   Preprint server

   bioRxiv

2. Elodie Lafont, Eric Chevet, TONY AVRIL, and Victoria MALTRET reviewed Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration

   • Cell Biology

   Review published

   July 23, 2024

   Preprint server

   bioRxiv