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Ten simple rules to build sustainable bioinformatics capacity using Nextflow and nf-core with a focus on early-mid career researchers: The Kids Research Institute Australia, case report.

by Patricia Agudelo-Romero, Talya Conradie, Jose A Caparros-Martin, David J Martino, Anthony Kicic, Stephen M. Stick, Christopher Hakkaart, Abhinav Sharma, and Theme Collaboration Group

Posted: March 18, 2025
Server: Zenodo
DOI: 10.5281/zenodo.15057024

The increasing adoption of high-throughput "omics" technologies has heightened the demand for standardized, scalable, and reproducible bioinformatics workflows. Nextflow and nf-core provide a robust framework for researchers, particularly early- and mid-career researchers (EMCRs), to navigate complex data analysis. At The Kids Research Institute Australia, we implemented a structured approach to bioinformatics capacity building using these tools. This paper presents ten practical rules that facilitated the successful adoption of Nextflow and nf-core, addressing implementation, knowledge gaps, resource allocation, and community support. Our experience serves as a guide for institutions aiming to establish sustainable bioinformatics capabilities and empower EMCRs.

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